ExplorEnz: EC 1.1.2.4

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1.1.2.4

Accepted name:

D-lactate dehydrogenase (cytochrome)

Reaction:

(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H⁺

Other name(s):

lactic acid dehydrogenase; D-lactate (cytochrome) dehydrogenase; cytochrome-dependent D-(-)-lactate dehydrogenase; D-lactate-cytochrome c reductase; D-(-)-lactic cytochrome c reductase

Systematic name:

(R)-lactate:cytochrome-c 2-oxidoreductase

Comments:

A flavoprotein (FAD).

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37250-79-6

References:

1.	Gregolin, C. and Singer, T.P. The lactate dehydrogenase of yeast. III. D-(-)-Lactate cytochrome c reductase, a zinc-flavoprotein from aerobic yeast. Biochim. Biophys. Acta 67 (1963) 201–218. [PMID: 13950255]
2.	Gregolin, C., Singer, T.P., Kearney, E.B. and Boeri, E. The formation and enzymatic properties of the various lactic dehydrogenases of yeast. Ann. N.Y. Acad. Sci. 94 (1961) 780–797. [DOI] [PMID: 13901630]
3.	Nygaard, A.P. D-(-)-Lactate cytochrome c reductase, a flavoprotein from yeast. J. Biol. Chem. 236 (1961) 920–925. [PMID: 13729965]
4.	Nygaard, A.P. Lactate dehydrogenases of yeast. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 7, Academic Press, New York, 1963, pp. 557–565.

[EC 1.1.2.4 created 1961]