ExplorEnz: EC 1.1.3.28

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1.1.3.28

Accepted name:

nucleoside oxidase

Reaction:

inosine + O₂ = 9-riburonosylhypoxanthine + H₂O
(1a) 2 inosine + O₂ = 2 5′-dehydroinosine + 2 H₂O
(1b) 2 5′-dehydroinosine + O₂ = 2 9-riburonosylhypoxanthine

Systematic name:

nucleoside:oxygen 5′-oxidoreductase

Comments:

Other purine and pyrimidine nucleosides (as well as 2′-deoxyribonucleosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5′-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.39, nucleoside oxidase (H₂O₂-forming), as it produces water rather than hydrogen peroxide.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 82599-71-1

References:

1.	Isono, Y., Sudo, T. and Hoshino, M. Purification and reaction of a new enzyme, nucleoside oxidase. Agric. Biol. Chem. 53 (1989) 1663–1669.
2.	Isono, Y., Sudo, T. and Hoshino, M. Properties of a new enzyme, nucleoside oxidase, from Pseudomonas maltophilia LB-86. Agric. Biol. Chem. 53 (1989) 1671–1677.

[EC 1.1.3.28 created 1992, modified 2001]