| EC |
1.1.3.37 |
| Accepted name: |
D-arabinono-1,4-lactone oxidase |
| Reaction: |
D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 |
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For diagram of reaction, click here |
| Glossary: |
dehydro-D-arabinono-1,4-lactone = (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one |
| Other name(s): |
D-arabinono-γ-lactone oxidase; ALO |
| Systematic name: |
D-arabinono-1,4-lactone:oxygen oxidoreductase |
| Comments: |
A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot [1]. With L-galactono-1,4-lactone as substrate, the product is L-ascorbate [3]. The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS no.: 5776-48-7; formula: C6H8O6), although it was referred to as a five-carbon compound [1]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 182372-12-9 |
| References: |
| 1. |
Huh, W.K., Kim, S.T., Yang, K.S., Seok, Y.J., Hah, Y.C. and Kang, S.O. Characterisation of D-arabinono-1,4-lactone oxidase from Candida albicans ATCC 10231. Eur. J. Biochem. 225 (1994) 1073–1079. [DOI] [PMID: 7957197] |
| 2. |
Huh, W.K., Lee, B.H., Kim, S.T., Kim, Y.R., Rhie, G.E., Baek, Y.W., Hwang, C.S., Lee, J.S. and Kang, S.O. D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae. Mol. Microbiol. 30 (1998) 895–903. [DOI] [PMID: 10094636] |
| 3. |
Lee, B.H., Huh, W.K., Kim, S.T., Lee, J.S. and Kang, S.O. Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli. Appl. Environ. Microbiol. 65 (1999) 4685–4687. [PMID: 10508108] |
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| [EC 1.1.3.37 created 1999] |
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