The Enzyme Database

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Accepted name: D-arabinono-1,4-lactone oxidase
Reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2
For diagram of reaction, click here
Glossary: dehydro-D-arabinono-1,4-lactone = (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one
Other name(s): D-arabinono-γ-lactone oxidase; ALO
Systematic name: D-arabinono-1,4-lactone:oxygen oxidoreductase
Comments: A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot [1]. With L-galactono-1,4-lactone as substrate, the product is L-ascorbate [3]. The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS no.: 5776-48-7; formula: C6H8O6), although it was referred to as a five-carbon compound [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 182372-12-9
1.  Huh, W.K., Kim, S.T., Yang, K.S., Seok, Y.J., Hah, Y.C. and Kang, S.O. Characterisation of D-arabinono-1,4-lactone oxidase from Candida albicans ATCC 10231. Eur. J. Biochem. 225 (1994) 1073–1079. [DOI] [PMID: 7957197]
2.  Huh, W.K., Lee, B.H., Kim, S.T., Kim, Y.R., Rhie, G.E., Baek, Y.W., Hwang, C.S., Lee, J.S. and Kang, S.O. D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae. Mol. Microbiol. 30 (1998) 895–903. [DOI] [PMID: 10094636]
3.  Lee, B.H., Huh, W.K., Kim, S.T., Lee, J.S. and Kang, S.O. Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli. Appl. Environ. Microbiol. 65 (1999) 4685–4687. [PMID: 10508108]
[EC created 1999]

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