| EC |
1.1.3.44 |
| Accepted name: |
6′′′-hydroxyneomycin C oxidase |
| Reaction: |
6′′′-deamino-6′′′-hydroxyneomycin C + O2 = 6′′′-deamino-6′′′-oxoneomycin C + H2O2 |
| Other name(s): |
neoG (gene name); neoQ (obsolete gene name) |
| Systematic name: |
6′′′-deamino-6′′′-hydroxyneomycin C:oxygen 6′′′-oxidoreductase |
| Comments: |
Contains FAD. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 2.6.1.95, neomycin C transaminase, to replace the 6′′′-hydroxy group of 6′′′-hydroxyneomycin C with an amino group.
Also catalyses EC 1.1.3.43, paromamine 6′-oxidase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Huang, F., Spiteller, D., Koorbanally, N.A., Li, Y., Llewellyn, N.M. and Spencer, J.B. Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. ChemBioChem 8 (2007) 283–288. [DOI] [PMID: 17206729] |
| 2. |
Clausnitzer, D., Piepersberg, W. and Wehmeier, U.F. The oxidoreductases LivQ and NeoQ are responsible for the different 6′-modifications in the aminoglycosides lividomycin and neomycin. J. Appl. Microbiol. 111 (2011) 642–651. [DOI] [PMID: 21689223] |
|
| [EC 1.1.3.44 created 2012] |
| |
|
| |
|
Printable version