| EC |
1.1.99.27 |
| Accepted name: |
(R)-pantolactone dehydrogenase (flavin) |
| Reaction: |
(R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor |
| Other name(s): |
2-dehydropantolactone reductase (flavin); 2-dehydropantoyl-lactone reductase (flavin); (R)-pantoyllactone dehydrogenase (flavin) |
| Systematic name: |
(R)-pantolactone:acceptor oxidoreductase (flavin-containing) |
| Comments: |
High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 140879-14-7 |
| References: |
| 1. |
Kataoka, M., Shimizu, S. and Yamada, H. Purification and characterization of a novel FMN-dependent enzyme. Membrane-bound L-(+)-pantoyl lactone dehydrogenase from Nocardia asteroides. Eur. J. Biochem. 204 (1992) 799–806. [DOI] [PMID: 1541293] |
|
| [EC 1.1.99.27 created 1999] |
| |
|
| |
|
Printable version