| EC |
1.1.99.7 |
| Accepted name: |
lactate—malate transhydrogenase |
| Reaction: |
(S)-lactate + oxaloacetate = pyruvate + malate |
| Other name(s): |
malate-lactate transhydrogenase |
| Systematic name: |
(S)-lactate:oxaloacetate oxidoreductase |
| Comments: |
Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This cofactor cannot be removed without denaturation of the protein. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 9077-15-0 |
| References: |
| 1. |
Allen, S.H.G. The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus. J. Biol. Chem. 241 (1966) 5266–5275. [DOI] [PMID: 4289051] |
| 2. |
Allen, S.H.G. and Patil, J.R. Studies on the structure and mechanism of action of the malate-lactate transhydrogenase. J. Biol. Chem. 247 (1972) 909–916. [DOI] [PMID: 4333516] |
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| [EC 1.1.99.7 created 1972] |
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