| EC |
1.10.3.4 |
| Accepted name: |
o-aminophenol oxidase |
| Reaction: |
4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O |
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For diagram of reaction, click here |
| Glossary: |
2-aminophenoxazin-3-one = isophenoxazine |
| Other name(s): |
isophenoxazine synthase; o-aminophenol:O2 oxidoreductase; 2-aminophenol:O2 oxidoreductase |
| Systematic name: |
2-aminophenol:oxygen oxidoreductase |
| Comments: |
A flavoprotein which catalyses a 6-electron oxidation. The enzyme from the plant Tecoma stans requires Mn2+ and FAD [1] whereas the fungus Pycnoporus coccineus requires Mn2+ and riboflavin 5′-phosphate [2], the bacteria Streptomyces antibioticus requires Cu2+ [4] and the plant Bauhenia monandra does not require any co-factors [3]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9013-85-8 |
| References: |
| 1. |
Nair, P.M. and Vaidynathan, C.S. Isophenoxazine synthase. Biochim. Biophys. Acta 81 (1964) 507–516. [PMID: 14170322] |
| 2. |
Nair, P.M. and Vining, L.C. Isophenoxazine synthase apoenzyme from Pycnoporus coccineus. Biochim. Biophys. Acta 96 (1965) 318–327. [DOI] [PMID: 14298835] |
| 3. |
Rao, P.V.S. and Vaidyanathan, C.S. Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra. Arch. Biochem. Biophys. 118 (1967) 388–394. [DOI] [PMID: 4166439] |
| 4. |
Barry, C.E., 3rd, Nayar, P.G. and Begley, T.P. Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin. Biochemistry 28 (1989) 6323–6333. [PMID: 2477054] |
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| [EC 1.10.3.4 created 1972, modified 2006] |
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