| EC |
1.12.1.4 |
| Accepted name: |
hydrogenase (NAD+, ferredoxin) |
| Reaction: |
2 H2 + NAD+ + 2 oxidized ferredoxin = 5 H+ + NADH + 2 reduced ferredoxin |
| Other name(s): |
bifurcating [FeFe] hydrogenase |
| Systematic name: |
hydrogen:NAD+, ferredoxin oxidoreductase |
| Comments: |
The enzyme from Thermotoga maritima contains a [FeFe] cluster (H-cluster) and iron-sulfur clusters. It works in the direction evolving hydrogen as a means of eliminating excess reducing equivalents. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Verhagen, M.F., O'Rourke, T. and Adams, M.W. The hyperthermophilic bacterium, Thermotoga maritima, contains an unusually complex iron-hydrogenase: amino acid sequence analyses versus biochemical characterization. Biochim. Biophys. Acta 1412 (1999) 212–229. [DOI] [PMID: 10482784] |
| 2. |
Schut, G.J. and Adams, M.W. The iron-hydrogenase of Thermotoga maritima utilizes ferredoxin and NADH synergistically: a new perspective on anaerobic hydrogen production. J. Bacteriol. 191 (2009) 4451–4457. [DOI] [PMID: 19411328] |
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| [EC 1.12.1.4 created 2011] |
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