ExplorEnz: EC 1.12.2.1

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1.12.2.1

Accepted name:

cytochrome-c₃ hydrogenase

Reaction:

H₂ + 2 ferricytochrome c₃ = 2 H⁺ + 2 ferrocytochrome c₃

Other name(s):

H₂:ferricytochrome c₃ oxidoreductase; cytochrome c₃ reductase; cytochrome hydrogenase; hydrogenase [ambiguous]

Systematic name:

hydrogen:ferricytochrome-c₃ oxidoreductase

Comments:

An iron-sulfur protein. Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also be reduced.

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9027-05-8

References:

1.	DerVartanian, D.V. and Le Gall, J. A monomolecular electron transfer chain: structure and function of cytochrome c₃. Biochim. Biophys. Acta 346 (1974) 79–99. [PMID: 4364940]
2.	Higuchi, Y., Yasuoka, N., Kakudo, M., Katsube, Y., Yagi, T. and Inokuchi, H. Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F. J. Biol. Chem. 262 (1987) 2823–2825. [PMID: 3546297]
3.	Rilkis, E. and Rittenberg, D. Some observations on the enzyme, hydrogenase. J. Biol. Chem. 236 (1961) 2526–2529. [PMID: 13741672]
4.	Sadana, J.C. and Morey, A.V. Purification and properties of the hydrogenase of Desulfovibrio desulfuricans. Biochim. Biophys. Acta 50 (1961) 153–163. [DOI] [PMID: 13745271]
5.	Volbeda, A., Charon, M.H., Piras, C., Hatchikian, E.C., Frey, M. and Fontecillacamps, J.C. Crystal-structure of the nickel-iron hydrogenase from Desulfovibrio gigas. Nature 373 (1995) 580–587. [DOI] [PMID: 7854413]
6.	Garcin, E., Vernede, X., Hatchikian, E.C., Volbeda, A., Frey, M. and Fontecilla-Camps, J.C. The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center. Structure 7 (1999) 557–566. [DOI] [PMID: 10378275]

[EC 1.12.2.1 created 1972, modified 2002]