ExplorEnz: EC 1.12.98.1

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1.12.98.1

Accepted name:

coenzyme F₄₂₀ hydrogenase

Reaction:

H₂ + oxidized coenzyme F₄₂₀ = reduced coenzyme F₄₂₀

For diagram of reaction, click here

Glossary:

coenzyme F₄₂₀ = N-(N-{O-[5-(8-hydroxy-2,4-dioxo-2,3,4,10-tetrahydropyrimido[4,5-b]quinolin-10-yl)-5-deoxy-L-ribityl-1-phospho]-(S)-lactyl}-γ-L-glutamyl)-L-glutamate

Other name(s):

8-hydroxy-5-deazaflavin-reducing hydrogenase; F₄₂₀-reducing hydrogenase; coenzyme F₄₂₀-dependent hydrogenase

Systematic name:

hydrogen:coenzyme F₄₂₀ oxidoreductase

Comments:

An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F₄₂₀, flavins and methyl viologen, but to a lesser extent. The hydrogen acceptor coenzyme F₄₂₀ is a deazaflavin derivative.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9027-05-8

References:

1.	Adams, M.W.W., Mortenson, L.E. and Chen, J.-S. Hydrogenase. Biochim. Biophys. Acta 594 (1981) 105–176. [PMID: 6786341]
2.	Yamazaki, S. A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue. J. Biol. Chem. 257 (1982) 7926–7929. [PMID: 6211447]
3.	Fox, J.A., Livingston, D.J., Orme-Johnson, W.H. and Walsh, C.T. 8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization. Biochemistry 26 (1987) 4219–4228. [PMID: 3663585]
4.	Muth, E., Morschel, E. and Klein, A. Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae. Eur. J. Biochem. 169 (1987) 571–577. [DOI] [PMID: 3121317]
5.	Baron, S.F. and Ferry, J.G. Purification and properties of the membrane-associated coenzyme F₄₂₀-reducing hydrogenase from Methanobacterium formicicum. J. Bacteriol. 171 (1989) 3846–3853. [DOI] [PMID: 2738024]

[EC 1.12.98.1 created 1989 as EC 1.12.99.1, transferred 2002 to EC 1.12.98.1]