| EC |
1.13.11.26 |
| Accepted name: |
peptide-tryptophan 2,3-dioxygenase |
| Reaction: |
[protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine |
| Glossary: |
N-formyl-L-kynurenine = (2S)-2-amino-4-[2-(formamido)phenyl]-4-oxobutanoic acid |
| Other name(s): |
pyrrolooxygenase; peptidyltryptophan 2,3-dioxygenase; tryptophan pyrrolooxygenase; [protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) |
| Systematic name: |
[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening) |
| Comments: |
Also acts on tryptophan. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37256-64-7 |
| References: |
| 1. |
Frydman, R.B., Tomaro, M.L. and Frydman, B. Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides. Biochim. Biophys. Acta 284 (1972) 80–89. [DOI] [PMID: 4403729] |
| 2. |
Camoretti-Mercado, B. and Frydman, R.B. Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of their substrate specificities using tryptophyl-containing peptides and proteins. Eur. J. Biochem. 156 (1986) 317–325. [DOI] [PMID: 3699018] |
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| [EC 1.13.11.26 created 1972, modified 2011] |
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