| EC |
1.13.11.3 |
| Accepted name: |
protocatechuate 3,4-dioxygenase |
| Reaction: |
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate |
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For diagram of benzoate metabolism, click here |
| Glossary: |
3,4-dihydroxybenzoate = protocatechuate |
| Other name(s): |
protocatechuate oxygenase; protocatechuic acid oxidase; protocatechuic 3,4-dioxygenase; protocatechuic 3,4-oxygenase; protocatechuate:oxygen 3,4-oxidoreductase (decyclizing) |
| Systematic name: |
protocatechuate:oxygen 3,4-oxidoreductase (ring-opening) |
| Comments: |
Requires Fe3+. The enzyme, which participates in the degradation of aromatic compounds, catalyses the intradiol addition of both oxygen atoms from molecular oxygen, resulting in ortho-cleavage of the aromatic ring. The type of cleavage leads to mineralization via the intermediate 3-oxoadipate. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9029-47-4 |
| References: |
| 1. |
Fujisawa, H. and Hayaishi, O. Protocatechuate 3,4-dioxygenase. I. Crystallization and characterization. J. Biol. Chem. 243 (1968) 2673–2681. [PMID: 4967959] |
| 2. |
Gross, S.R., Gafford, R.D. and Tatum, E.L. The metabolism of protocatechuic acid by Neurospora. J. Biol. Chem. 219 (1956) 781–796. [PMID: 13319299] |
| 3. |
Stanier, R.Y. and Ingraham, J.L. Protocatechuic acid oxidase. J. Biol. Chem. 210 (1954) 799–820. [PMID: 13211618] |
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| [EC 1.13.11.3 created 1961 as EC 1.99.2.3, transferred 1965 to EC 1.13.1.3, transferred 1972 to EC 1.13.11.3] |
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