The Enzyme Database

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Accepted name: arachidonate 12-lipoxygenase
Reaction: arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Other name(s): Δ12-lipoxygenase; 12-lipoxygenase; 12Δ-lipoxygenase; C-12 lipoxygenase; 12S-lipoxygenase; leukotriene A4 synthase; LTA4 synthase
Systematic name: arachidonate:oxygen 12-oxidoreductase
Comments: The product is rapidly reduced to the corresponding 12S-hydroxy compound.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 82391-43-3
1.  Hamberg, M. and Samuelsson, B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Natl. Acad. Sci. USA 71 (1974) 3400–3404. [DOI] [PMID: 4215079]
2.  Nugteren, D.H. Arachidonate lipoxygenase in blood platelets. Biochim. Biophys. Acta 380 (1975) 299–307. [DOI] [PMID: 804329]
3.  Wallach, D.P. and Brown, V.R. A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases. Biochim. Biophys. Acta 663 (1981) 361–372. [DOI] [PMID: 6783111]
[EC created 1983]

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