| EC |
1.13.11.31 |
| Accepted name: |
arachidonate 12-lipoxygenase |
| Reaction: |
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate |
| Other name(s): |
Δ12-lipoxygenase; 12-lipoxygenase; 12Δ-lipoxygenase; C-12 lipoxygenase; 12S-lipoxygenase; leukotriene A4 synthase; LTA4 synthase |
| Systematic name: |
arachidonate:oxygen 12-oxidoreductase |
| Comments: |
The product is rapidly reduced to the corresponding 12S-hydroxy compound. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 82391-43-3 |
| References: |
| 1. |
Hamberg, M. and Samuelsson, B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Natl. Acad. Sci. USA 71 (1974) 3400–3404. [DOI] [PMID: 4215079] |
| 2. |
Nugteren, D.H. Arachidonate lipoxygenase in blood platelets. Biochim. Biophys. Acta 380 (1975) 299–307. [DOI] [PMID: 804329] |
| 3. |
Wallach, D.P. and Brown, V.R. A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases. Biochim. Biophys. Acta 663 (1981) 361–372. [DOI] [PMID: 6783111] |
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| [EC 1.13.11.31 created 1983] |
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