| EC |
1.13.11.46 |
| Accepted name: |
4-hydroxymandelate synthase |
| Reaction: |
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 |
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For diagram of 4-hydroxyphenylpyruvate metabolites, click here |
| Glossary: |
(S)-4-hydroxymandelate = (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate
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| Other name(s): |
4-hydroxyphenylpyruvate dioxygenase II |
| Systematic name: |
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating) |
| Comments: |
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 280566-04-3 |
| References: |
| 1. |
Hubbard, B.K., Thomas, M.G. and Walsh, C.T. Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. Chem. Biol. 7 (2000) 931–942. [DOI] [PMID: 11137816] |
| 2. |
Choroba, O.W., Williams, D.H. and Spencer, J.B. Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine. J. Am. Chem. Soc. 122 (2000) 5389–5390. |
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| [EC 1.13.11.46 created 2001] |
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