The Enzyme Database

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Accepted name: acetylacetone-cleaving enzyme
Reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal
Glossary: 2-oxopropanal = methylglyoxal
Other name(s): Dke1; acetylacetone dioxygenase; diketone cleaving dioxygenase; diketone cleaving enzyme
Systematic name: acetylacetone:oxygen oxidoreductase
Comments: An iron(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 524047-53-8
1.  Straganz, G.D., Glieder, A., Brecker, L., Ribbons, D.W. and Steiner, W. Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii. Biochem. J. 369 (2003) 573–581. [DOI] [PMID: 12379146]
[EC created 2003]

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