| EC |
1.13.11.57 |
| Accepted name: |
gallate dioxygenase |
| Reaction: |
3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate |
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For diagram of the protocatechuate 3,4-cleavage pathway, click here |
| Glossary: |
3,4,5-trihydroxybenzoate = gallate |
| Other name(s): |
GalA; gallate:oxygen oxidoreductase |
| Systematic name: |
3,4,5-trihydroxybenzoate:oxygen oxidoreductase |
| Comments: |
Contains non-heme Fe2+. The enzyme is a ring-cleavage dioxygenase that acts specifically on 3,4,5-trihydroxybenzoate to produce the keto-tautomer of 4-oxalomesaconate [1,2]. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Nogales, J., Canales, A., Jiménez-Barbero, J., García, J.L. and Díaz, E. Molecular characterization of the gallate dioxygenase from Pseudomonas putida KT2440. The prototype of a new subgroup of extradiol dioxygenases. J. Biol. Chem. 280 (2005) 35382–35390. [DOI] [PMID: 16030014] |
| 2. |
Nogales, J., Canales, A., Jiménez-Barbero, J., Serra B., Pingarrón, J. M., García, J. L. and Díaz, E. Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida. Mol. Microbiol. 79 (2011) 359–374. [DOI] [PMID: 21219457] |
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| [EC 1.13.11.57 created 2011] |
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