| EC |
1.13.11.62 |
| Accepted name: |
linoleate 10R-lipoxygenase |
| Reaction: |
linoleate + O2 = (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate |
| Glossary: |
linoleate = (9Z,12Z)-octadeca-9,12-dienoate |
| Other name(s): |
10R-DOX; (10R)-dioxygenase; 10R-dioxygenase |
| Systematic name: |
linoleate:oxygen (10R)-oxidoreductase |
| Comments: |
The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Garscha, U. and Oliw, E.H. Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis of (10R)-dioxygenase with epoxyalcohol synthase activity. J. Biol. Chem. 284 (2009) 13755–13765. [DOI] [PMID: 19289462] |
| 2. |
Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. Biochim. Biophys. Acta 1801 (2010) 503–507. [DOI] [PMID: 20045744] |
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| [EC 1.13.11.62 created 2011] |
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