ExplorEnz: EC 1.13.11.81

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1.13.11.81

Accepted name:

7,8-dihydroneopterin oxygenase

Reaction:

7,8-dihydroneopterin + O₂ = 7,8-dihydroxanthopterin + formate + glycolaldehyde

For diagram of methanopterin biosynthesis (part 1), click here

Glossary:

7,8-dihydroneopterin = 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydropteridin-4(3H)-one
7,8-dihydroxanthopterin = 2-amino-3,5,7,8-tetrahydropteridin-4,6-dione

Systematic name:

7,8-dihydroneopterin:oxygen oxidoreductase

Comments:

The enzyme from the bacterium Mycobacterium tuberculosis is multifunctional and also catalyses the epimerisation of the 2′-hydroxy group of 7,8-dihydroneopterin (EC 5.1.99.8, 7,8-dihydroneopterin epimerase) and the reaction of EC 4.1.2.25 (dihydroneopterin aldolase).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Czekster, C.M. and Blanchard, J.S. One substrate, five products: reactions catalyzed by the dihydroneopterin aldolase from Mycobacterium tuberculosis. J. Am. Chem. Soc. 134 (2012) 19758–19771. [DOI] [PMID: 23150985]

[EC 1.13.11.81 created 2015]