ExplorEnz: EC 1.13.11.94

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1.13.11.94

Accepted name:

4-vinylguaiacol dioxygenase

Reaction:

(1) 4-vinylguaiacol + O₂ = vanillin + formaldehyde
(2) 4-vinylphenol + O₂ = 4-hydroxybenzaldehyde + formaldehyde

Glossary:

4-vinylguaiacol = 2-methoxy-4-vinylphenol

Other name(s):

Ado; aromatic dioxygenase

Systematic name:

4-vinylguaiacol:oxygen oxidoreductase

Comments:

The enzyme was isolated from the bacterium Caulobacter segnis and the fungus Thermothelomyces thermophilus. It is used as an economic option in lignin degradation since it does not require a cofactor.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Furuya, T., Miura, M. and Kino, K. A coenzyme-independent decarboxylase/oxygenase cascade for the efficient synthesis of vanillin. Chembiochem 15 (2014) 2248–2254. [DOI] [PMID: 25164030]
2.	Ni, J., Wu, Y.T., Tao, F., Peng, Y. and Xu, P. A coenzyme-free biocatalyst for the value-added utilization of lignin-derived aromatics. J. Am. Chem. Soc. 140 (2018) 16001–16005. [DOI] [PMID: 30376327]

[EC 1.13.11.94 created 2024]