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Your query returned 1 entry. Printable version
EC | 1.14.11.21 | ||||||||||
Accepted name: | clavaminate synthase | ||||||||||
Reaction: | (1) deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 (2) proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O (3) dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O |
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For diagram of clavulanate biosynthesis, click here | |||||||||||
Other name(s): | clavaminate synthase 2; clavaminic acid synthase | ||||||||||
Systematic name: | deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | ||||||||||
Comments: | Contains nonheme iron. Catalyses three separate oxidative reactions in the pathway for the biosythesis of the β-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 122799-56-8 | ||||||||||
References: |
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