EC |
1.14.11.4 |
Accepted name: |
procollagen-lysine 5-dioxygenase |
Reaction: |
[procollagen]-L-lysine + 2-oxoglutarate + O2 = [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 |
Other name(s): |
lysine hydroxylase; lysine,2-oxoglutarate 5-dioxygenase; protocollagen lysine dioxygenase; collagen lysine hydroxylase; lysine-2-oxoglutarate dioxygenase; lysyl hydroxylase; lysylprotocollagen dioxygenase; protocollagen lysyl hydroxylase; peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase; peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase; protocollagen lysine hydroxylase; procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating); L-lysine-[procollagen],2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) |
Systematic name: |
[procollagen]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) |
Comments: |
Requires Fe2+ and ascorbate. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9059-25-0 |
References: |
1. |
Hausmann, E. Cofactor requirements for the enzymatic hydroxylation of lysine in a polypeptide precursor of collagen. Biochim. Biophys. Acta 133 (1967) 591–598. [DOI] [PMID: 6033801] |
2. |
Rhoads, R.E. and Udenfriend, S. Decarboxylation of α-ketoglutarate coupled to collagen proline hydroxylase. Proc. Natl. Acad. Sci. USA 60 (1968) 1473–1478. [DOI] [PMID: 5244754] |
3. |
Puistola, U., Turpeenniemi-Hujanen, T.M., Myllyla, R. and Kivirikko, K.I. Studies on the lysyl hydroxylase reaction. I. Initial velocity kinetics and related aspects. Biochim. Biophys. Acta 611 (1980) 40–50. [DOI] [PMID: 6766066] |
4. |
Puistola, U., Turpeenniemi-Hujanen, T.M., Myllyla, R. and Kivirikko, K.I. Studies on the lysyl hydroxylase reaction. II. Inhibition kinetics and the reaction mechanism. Biochim. Biophys. Acta 611 (1980) 51–60. [DOI] [PMID: 6766067] |
|
[EC 1.14.11.4 created 1972, modified 1983] |
|
|
|
|