EC	1.14.11.44
Accepted name:	(R)-dichlorprop dioxygenase (2-oxoglutarate)
Reaction:	(1) (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + pyruvate + succinate + CO2 (2) (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + pyruvate + succinate + CO2
Glossary:	(R)-2-(4-chloro-2-methylphenoxy)propanoate = (R)-mecoprop (R)-(2,4-dichlorophenoxy)propanoate = (R)-dichlorprop
Other name(s):	RdpA; α-ketoglutarate-dependent (R)-dichlorprop dioxygenase; (R)-phenoxypropionate/α-ketoglutarate-dioxygenase; 2-oxoglutarate-dependent (R)-dichlorprop dioxygenase; (R)-mecoprop dioxygenase; 2-oxoglutarate-dependent (R)-mecoprop dioxygenase
Systematic name:	(R)-2-(4-chloro-2-methylphenoxy)propanoate,2-oxoglutarate:oxygen oxidoreductase (pyruvate-forming)
Comments:	Fe2+-dependent enzyme. The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop [1,2].
References:	1.  Westendorf, A., Benndorf, D., Muller, R.H. and Babel, W. The two enantiospecific dichlorprop/α-ketoglutarate-dioxygenases from Delftia acidovorans MC1 – protein and sequence data of RdpA and SdpA. Microbiol. Res. 157 (2002) 317–322. [PMID: 12501996] 2.  Muller, T.A., Fleischmann, T., van der Meer, J.R. and Kohler, H.P. Purification and characterization of two enantioselective α-ketoglutarate-dependent dioxygenases, RdpA and SdpA, from Sphingomonas herbicidovorans MH. Appl. Environ. Microbiol. 72 (2006) 4853–4861. [PMID: 16820480] 3.  Muller, T.A., Zavodszky, M.I., Feig, M., Kuhn, L.A. and Hausinger, R.P. Structural basis for the enantiospecificities of R- and S-specific phenoxypropionate/α-ketoglutarate dioxygenases. Protein Sci. 15 (2006) 1356–1368. [PMID: 16731970]
[EC 1.14.11.44 created 2013]