ExplorEnz: EC 1.14.11.48

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1.14.11.48

Accepted name:

xanthine dioxygenase

Reaction:

xanthine + 2-oxoglutarate + O₂ = urate + succinate + CO₂

For diagram of AMP catabolism, click here

Other name(s):

XanA; α-ketoglutarate-dependent xanthine hydroxylase

Systematic name:

xanthine,2-oxoglutarate:oxygen oxidoreductase

Comments:

Requires Fe²⁺ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Cultrone, A., Scazzocchio, C., Rochet, M., Montero-Moran, G., Drevet, C. and Fernandez-Martin, R. Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via α-ketoglutarate-dependent dioxygenases. Mol. Microbiol. 57 (2005) 276–290. [DOI] [PMID: 15948966]
2.	Montero-Moran, G.M., Li, M., Rendon-Huerta, E., Jourdan, F., Lowe, D.J., Stumpff-Kane, A.W., Feig, M., Scazzocchio, C. and Hausinger, R.P. Purification and characterization of the Fe^II- and α-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans. Biochemistry 46 (2007) 5293–5304. [DOI] [PMID: 17429948]
3.	Li, M., Muller, T.A., Fraser, B.A. and Hausinger, R.P. Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans. Arch. Biochem. Biophys. 470 (2008) 44–53. [DOI] [PMID: 18036331]

[EC 1.14.11.48 created 2015]