The Enzyme Database

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EC 1.14.11.49     
Accepted name: uridine-5′-phosphate dioxygenase
Reaction: UMP + 2-oxoglutarate + O2 = 5′-dehydrouridine + succinate + CO2 + phosphate
For diagram of pyrimidine biosynthesis, click here
Glossary: 5′-dehydrouridine = uridine-5′-aldehyde
Other name(s): lipL (gene name)
Systematic name: UMP,2-oxoglutarate:oxygen oxidoreductase
Comments: The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5′-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Yang, Z., Chi, X., Funabashi, M., Baba, S., Nonaka, K., Pahari, P., Unrine, J., Jacobsen, J.M., Elliott, G.I., Rohr, J. and Van Lanen, S.G. Characterization of LipL as a non-heme, Fe(II)-dependent α-ketoglutarate:UMP dioxygenase that generates uridine-5′-aldehyde during A-90289 biosynthesis. J. Biol. Chem. 286 (2011) 7885–7892. [DOI] [PMID: 21216959]
2.  Yang, Z., Unrine, J., Nonaka, K. and Van Lanen, S.G. Fe(II)-dependent, uridine-5′-monophosphate α-ketoglutarate dioxygenases in the synthesis of 5′-modified nucleosides. Methods Enzymol. 516 (2012) 153–168. [DOI] [PMID: 23034228]
[EC 1.14.11.49 created 2015]
 
 


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