| EC |
1.14.11.57 |
| Accepted name: |
L-proline trans-4-hydroxylase |
| Reaction: |
L-proline + 2-oxoglutarate + O2 = trans-4-hydroxy-L-proline + succinate + CO2 |
| Systematic name: |
L-proline,2-oxoglutarate:oxygen oxidoreductase (trans-4-hydroxylating) |
| Comments: |
Requires Fe2+ and ascorbate. The enzyme, isolated from multiple bacterial species, only produces trans-4-hydroxy-L-proline (cf. EC 1.14.11.56, L-proline cis-4-hydroxylase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Lawrence, C.C., Sobey, W.J., Field, R.A., Baldwin, J.E. and Schofield, C.J. Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis. Biochem. J. 313 (1996) 185–191. [PMID: 8546682] |
| 2. |
Shibasaki, T., Mori, H., Chiba, S. and Ozaki, A. Microbial proline 4-hydroxylase screening and gene cloning. Appl. Environ. Microbiol. 65 (1999) 4028–4031. [PMID: 10473412] |
|
| [EC 1.14.11.57 created 2017] |
| |
|
| |
|
Printable version