ExplorEnz: EC 1.14.11.60

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1.14.11.60

Accepted name:

scopoletin 8-hydroxylase

Reaction:

scopoletin + 2-oxoglutarate + O₂ = fraxetin + succinate + CO₂

Glossary:

fraxetin = 7,8-dihydroxy-6-methoxy-2H-chromen-2-one
scopoletin = 7-hydroxy-6-methoxy-2H-chromen-2-one

Other name(s):

S8H (gene name)

Systematic name:

scopoletin,2-oxoglutarate:oxygen oxidoreductase (8-hydroxylating)

Comments:

Requires iron(II) and ascorbate. A protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Siwinska, J., Siatkowska, K., Olry, A., Grosjean, J., Hehn, A., Bourgaud, F., Meharg, A.A., Carey, M., Lojkowska, E. and Ihnatowicz, A. Scopoletin 8-hydroxylase: a novel enzyme involved in coumarin biosynthesis and iron-deficiency responses in Arabidopsis. J. Exp. Bot. 69 (2018) 1735–1748. [PMID: 29361149]
2.	Rajniak, J., Giehl, R.FH., Chang, E., Murgia, I., von Wiren, N. and Sattely, E.S. Biosynthesis of redox-active metabolites in response to iron deficiency in plants. Nat. Chem. Biol. 14 (2018) 442–450. [PMID: 29581584]

[EC 1.14.11.60 created 2018]