| EC |
1.14.12.11 |
| Accepted name: |
toluene dioxygenase |
| Reaction: |
toluene + NADH + H+ + O2 = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+ |
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For diagram of reaction, click here |
| Other name(s): |
toluene 2,3-dioxygenase |
| Systematic name: |
toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating) |
| Comments: |
A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase, and a ferredoxin. Some other aromatic compounds, including ethylbenzene, 4-xylene and some halogenated toluenes, are converted into the corresponding cis-dihydrodiols. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 120038-36-0 |
| References: |
| 1. |
Renganathan, V. Possible involvement of toluene-2,3-dioxygenase in defluorination of 3-fluoro-substituted benzenes by toluene-degrading Pseudomonas sp. strain T-12. Appl. Exp. Microbiol. 55 (1989) 330–334. [PMID: 16347845] |
| 2. |
Subramanian, V., Liu, T.-N., Yeh, W.K. and Gibson, D.T. Toluene dioxygenase: purification of an iron-sulfur protein by affinity chromatography. Biochem. Biophys. Res. Commun. 91 (1979) 1131–1139. [DOI] [PMID: 526270] |
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| [EC 1.14.12.11 created 1992] |
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