| EC |
1.14.12.16 |
| Accepted name: |
2-hydroxyquinoline 5,6-dioxygenase |
| Reaction: |
quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+ |
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For diagram of reaction, click here |
| Other name(s): |
2-oxo-1,2-dihydroquinoline 5,6-dioxygenase; quinolin-2-ol 5,6-dioxygenase; quinolin-2(1H)-one 5,6-dioxygenase |
| Systematic name: |
quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating) |
| Comments: |
3-Methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also substrates. Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 172399-50-7 |
| References: |
| 1. |
Schach, S.B., Tshisuaka, B., Fetzner, S. and Lingens, F. Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation. Eur. J. Biochem. 232 (1995) 536–544. [DOI] [PMID: 7556204] |
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| [EC 1.14.12.16 created 1999] |
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