ExplorEnz: EC 1.14.13.1

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1.14.13.1

Accepted name:

salicylate 1-monooxygenase

Reaction:

salicylate + NADH + 2 H⁺ + O₂ = catechol + NAD⁺ + H₂O + CO₂

Other name(s):

salicylate hydroxylase; salicylate 1-hydroxylase; salicylate monooxygenase; salicylate hydroxylase (decarboxylating)

Systematic name:

salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)

Comments:

A flavoprotein (FAD).

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9059-28-3

References:

1.	Suzuki, K., Takemori, S. and Katagiri, M. Mechanism of the salicylate hydroxylase reaction. IV. Fluorimetric analysis of the complex formation. Biochim. Biophys. Acta 191 (1969) 77–85. [DOI] [PMID: 4390441]
2.	Takemori, S., Yasuda, H., Mihara, K., Suzuki, K. and Katagiri, M. Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex. Biochim. Biophys. Acta 191 (1969) 58–68. [DOI] [PMID: 4898626]
3.	Takemori, S., Yasuda, H., Mihara, K., Suzuki, K. and Katagiri, M. Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin. Biochim. Biophys. Acta 191 (1969) 69–76. [DOI] [PMID: 4309912]
4.	Yamamoto, S., Katagiri, M., Maeno, H. and Hayaishi, O. Salicylate hydroxylase, a monooxygenase requiring flavin adenine dinucleotide. J. Biol. Chem. 240 (1965) 3408–3413. [PMID: 14321380]

[EC 1.14.13.1 created 1972]