The Enzyme Database

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Accepted name: 2,6-dihydroxypyridine 3-monooxygenase
Reaction: 2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O
For diagram of nicotine catabolism by arthrobacter, click here
Other name(s): 2,6-dihydroxypyridine oxidase
Systematic name: 2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)
Comments: A flavoprotein.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 39279-38-4
1.  Holmes, P.E. and Rittenberg, S.C. The bacterial oxidation of nicotine. VII. Partial purification and properties of 2,6-dihydroxypyridine oxidase. J. Biol. Chem. 247 (1972) 7622–7627. [PMID: 4344227]
2.  Holmes, P.E., Rittenberg, S.C. and Knackmuss, H.J. The bacterial oxidation of nicotine. 8. Synthesis of 2,3,6-trihydroxypyridine and accumulation and partial characterization of the product of 2,6-dihydroxypyridine oxidation. J. Biol. Chem. 247 (1972) 7628–7633. [PMID: 4636328]
[EC created 1976]

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