| EC |
1.14.13.128 |
| Accepted name: |
7-methylxanthine demethylase |
| Reaction: |
7-methylxanthine + O2 + NAD(P)H + H+ = xanthine + NAD(P)+ + H2O + formaldehyde |
| Other name(s): |
ndmC (gene name) |
| Systematic name: |
7-methylxanthine:oxygen oxidoreductase (demethylating) |
| Comments: |
A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida prefers NADH over NADPH. The enzyme is specific for 7-methylxanthine [2]. Forms part of the caffeine degradation pathway. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Summers, R.M., Louie, T.M., Yu, C.L. and Subramanian, M. Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source. Microbiology 157 (2011) 583–592. [DOI] [PMID: 20966097] |
| 2. |
Summers, R.M., Louie, T.M., Yu, C.L., Gakhar, L., Louie, K.C. and Subramanian, M. Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids. J. Bacteriol. 194 (2012) 2041–2049. [DOI] [PMID: 22328667] |
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| [EC 1.14.13.128 created 2011] |
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