| EC |
1.14.13.172 |
| Accepted name: |
salicylate 5-hydroxylase |
| Reaction: |
salicylate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O |
| Glossary: |
2,5-dihydroxybenzoate = gentisate |
| Other name(s): |
nagG (gene name); nagH (gene name) |
| Systematic name: |
salicylate,NADH:oxygen oxidoreductase (5-hydroxylating) |
| Comments: |
This enzyme, which was characterized from the bacterium Ralstonia sp. U2, comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.7, ferredoxin—NAD(P)+ reductase), an iron-sulfur oxygenase, and ferredoxin. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Fuenmayor, S.L., Wild, M., Boyes, A.L. and Williams, P.A. A gene cluster encoding steps in conversion of naphthalene to gentisate in Pseudomonas sp. strain U2. J. Bacteriol. 180 (1998) 2522–2530. [PMID: 9573207] |
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| [EC 1.14.13.172 created 2013] |
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