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Your query returned 1 entry. 
Printable version
| EC | 1.14.13.200 | ||||||
| Accepted name: | tetracenomycin A2 monooxygenase-dioxygenase | ||||||
| Reaction: | tetracenomycin A2 + 2 O2 + 2 NADPH + 2 H+ = tetracenomycin C + 2 NADP+ + H2O | ||||||
| For diagram of tetracenomycin biosynthesis, click here | |||||||
| Glossary: | tetracenomycin A2 = methyl 10,12-dihydroxy-3,8-dimethoxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate tetracenomycin C = methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate |
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| Other name(s): | TcmG; ElmG; tetracenomycin A2,NAD(P)H:O2 oxidoreductase (tetracenomycin C forming) | ||||||
| Systematic name: | tetracenomycin A2,NADPH:oxygen oxidoreductase (tetracenomycin-C-forming) | ||||||
| Comments: | Isolated from the bacterium Streptomyces glaucescens. The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis. The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide. Water opens the epoxide giving two hydroxy groups. The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
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