| EC |
1.14.13.223 |
| Accepted name: |
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase |
| Reaction: |
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + NADH + H+ + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + NAD+ + H2O |
| Glossary: |
anthranilate = 2-aminobenzoate |
| Other name(s): |
sibG (gene name) |
| Systematic name: |
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein],NADH:oxygen oxidoreductase (5-hydroxylating) |
| Comments: |
A flavoprotein (FAD). The enzyme, characterized from the bacterium Streptosporangium sibiricum, is involved in the biosynthesis of the antitumor antibiotic sibiromycin. The enzyme is not active with free 3-hydroxy-4-methylanthranilate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Giessen, T.W., Kraas, F.I. and Marahiel, M.A. A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. Biochemistry 50 (2011) 5680–5692. [DOI] [PMID: 21612226] |
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| [EC 1.14.13.223 created 2016] |
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