ExplorEnz: EC 1.14.13.227

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1.14.13.227

Accepted name:

propane 2-monooxygenase

Reaction:

propane + NADH + H⁺ + O₂ = propan-2-ol + NAD⁺ + H₂O

Glossary:

propan-2-ol = isopropanol

Other name(s):

prmABCD (gene names)

Systematic name:

propane,NADH:oxygen oxidoreductase (2-hydroxylating)

Comments:

The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Kotani, T., Yamamoto, T., Yurimoto, H., Sakai, Y. and Kato, N. Propane monooxygenase and NAD⁺-dependent secondary alcohol dehydrogenase in propane metabolism by Gordonia sp. strain TY-5. J. Bacteriol. 185 (2003) 7120–7128. [DOI] [PMID: 14645271]
2.	Sharp, J.O., Sales, C.M., LeBlanc, J.C., Liu, J., Wood, T.K., Eltis, L.D., Mohn, W.W. and Alvarez-Cohen, L. An inducible propane monooxygenase is responsible for N-nitrosodimethylamine degradation by Rhodococcus sp. strain RHA1. Appl. Environ. Microbiol. 73 (2007) 6930–6938. [DOI] [PMID: 17873074]
3.	Furuya, T., Hirose, S., Osanai, H., Semba, H. and Kino, K. Identification of the monooxygenase gene clusters responsible for the regioselective oxidation of phenol to hydroquinone in mycobacteria. Appl. Environ. Microbiol. 77 (2011) 1214–1220. [DOI] [PMID: 21183637]

[EC 1.14.13.227 created 2016]