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Your query returned 1 entry. 
Printable version
| EC | 1.14.13.243 | ||||||
| Accepted name: | toluene 2-monooxygenase | ||||||
| Reaction: | (1) toluene + NADH + H+ + O2 = 2-methylphenol + NAD+ + H2O (2) 2-methylphenol + NADH + H+ + O2 = 3-methylcatechol + NAD+ + H2O |
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| Other name(s): | tomA1/2/3/4/5 (gene names); toluene ortho-monooxygenase | ||||||
| Systematic name: | toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating) | ||||||
| Comments: | The enzyme, characterized from the bacterium Burkholderia cepacia, belongs to a class of nonheme, oxygen-dependent diiron enzymes. It contains a hydroxylase component with two binuclear iron centers, an NADH-oxidoreductase component containing FAD and a [2Fe-2S] iron-sulfur cluster, and a third component involved in electron transfer between the hydroxylase and the reductase. The enzyme dihydroxylates its substrate in two sequential hydroxylations, initially forming 2-methylphenol, which is hydroxylated to 3-methylcatechol. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
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