The Enzyme Database

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Accepted name: putrescine N-hydroxylase
Reaction: putrescine + NADPH + H+ + O2 = N-hydroxyputrescine + NADP+ + H2O
Other name(s): alcA (gene name); pubA (gene name); fbsI (gene name)
Systematic name: putrescine,NADPH:oxygen oxidoreductase (N-hydroxylating)
Comments: Contains FAD. The enzyme, characterized from multiple bacterial species, participates in the biosynthesis of assorted siderophores.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Kadi, N., Arbache, S., Song, L., Oves-Costales, D. and Challis, G.L. Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species: PubC catalyzes cyclodimerization of N-hydroxy-N-succinylputrescine. J. Am. Chem. Soc. 130 (2008) 10458–10459. [DOI] [PMID: 18630910]
2.  Li, B., Lowe-Power, T., Kurihara, S., Gonzales, S., Naidoo, J., MacMillan, J.B., Allen, C. and Michael, A.J. Functional identification of putrescine C- and N-hydroxylases. ACS Chem. Biol. 11 (2016) 2782–2789. [DOI] [PMID: 27541336]
3.  Lyons, N.S., Bogner, A.N., Tanner, J.J. and Sobrado, P. Kinetic and structural characterization of a flavin-dependent putrescine N-hydroxylase from Acinetobacter baumannii. Biochemistry 61 (2022) 2607–2620. [DOI] [PMID: 36314559]
[EC created 2024]

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