| EC |
1.14.13.34 |
| Accepted name: |
leukotriene-E4 20-monooxygenase |
| Reaction: |
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + H+ + O2 = 20-hydroxyleukotriene E4 + NADP+ + H2O |
| Other name(s): |
leukotriene-E4 ω-hydroxylase |
| Systematic name: |
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating) |
| Comments: |
Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.13.30 leukotriene-B4 20-monooxygenase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 111940-51-3 |
| References: |
| 1. |
Örning, L. ω-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of ω-hydroxy and ω-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4. Eur. J. Biochem. 170 (1987) 77–85. [PMID: 2826163] |
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| [EC 1.14.13.34 created 1989] |
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