| EC |
1.14.13.92 |
| Accepted name: |
phenylacetone monooxygenase |
| Reaction: |
phenylacetone + NADPH + H+ + O2 = benzyl acetate + NADP+ + H2O |
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For diagram of reaction, click here |
| Other name(s): |
PAMO |
| Systematic name: |
phenylacetone,NADPH:oxygen oxidoreductase |
| Comments: |
A flavoprotein (FAD). NADH cannot replace NADPH as coenzyme. In addition to phenylacetone, which is the best substrate found to date, this Baeyer-Villiger monooxygenase can oxidize other aromatic ketones [1-(4-hydroxyphenyl)propan-2-one, 1-(4-hydroxyphenyl)propan-2-one and 3-phenylbutan-2-one], some alipatic ketones (e.g. dodecan-2-one) and sulfides (e.g. 1-methyl-4-(methylsulfanyl)benzene). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 1005768-90-0 |
| References: |
| 1. |
Malito, E., Alfieri, A., Fraaije, M.W. and Mattevi, A. Crystal structure of a Baeyer-Villiger monooxygenase. Proc. Natl. Acad. Sci. USA 101 (2004) 13157–13162. [DOI] [PMID: 15328411] |
| 2. |
Fraaije, M.W., Wu, J., Heuts, D.P., van Hellemond, E.W., Spelberg, J.H. and Janssen, D.B. Discovery of a thermostable Baeyer-Villiger monooxygenase by genome mining. Appl. Microbiol. Biotechnol. 66 (2005) 393–400. [DOI] [PMID: 15599520] |
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| [EC 1.14.13.92 created 2005] |
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