ExplorEnz: EC 1.14.14.10

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1.14.14.10

Accepted name:

nitrilotriacetate monooxygenase

Reaction:

nitrilotriacetate + FMNH₂ + H⁺ + O₂ = iminodiacetate + glyoxylate + FMN + H₂O

Systematic name:

nitrilotriacetate,FMNH₂:oxygen oxidoreductase (glyoxylate-forming)

Comments:

Requires Mg²⁺. The enzyme from Aminobacter aminovorans (previously Chelatobacter heintzii) is part of a two component system that also includes EC 1.5.1.42 (FMN reductase), which provides reduced flavin mononucleotide for this enzyme.

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Uetz, T., Schneider, R., Snozzi, M. and Egli, T. Purification and characterization of a two-component monooxygenase that hydroxylates nitrilotriacetate from "Chelatobacter" strain ATCC 29600. J. Bacteriol. 174 (1992) 1179–1188. [DOI] [PMID: 1735711]
2.	Knobel, H.R., Egli, T. and van der Meer, J.R. Cloning and characterization of the genes encoding nitrilotriacetate monooxygenase of Chelatobacter heintzii ATCC 29600. J. Bacteriol. 178 (1996) 6123–6132. [DOI] [PMID: 8892809]
3.	Xu, Y., Mortimer, M.W., Fisher, T.S., Kahn, M.L., Brockman, F.J. and Xun, L. Cloning, sequencing, and analysis of a gene cluster from Chelatobacter heintzii ATCC 29600 encoding nitrilotriacetate monooxygenase and NADH:flavin mononucleotide oxidoreductase. J. Bacteriol. 179 (1997) 1112–1116. [DOI] [PMID: 9023192]

[EC 1.14.14.10 created 2011]