| EC |
1.14.14.167 |
| Accepted name: |
(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase |
| Reaction: |
(13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine + [reduced NADPH—hemoprotein reductase] + O2 = (13S,14R)-13-O-acetyl-1,8-dihydroxy-cis-N-methylcanadine + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of noscapine biosynthesis, click here |
| Other name(s): |
CYP82X1 (gene name) |
| Systematic name: |
(13S,14R)-13-O-acetyl-1-hydroxy-cis-N-methylcanadine 8-hydroxylase,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating) |
| Comments: |
This cytochrome P-450 (heme-thiolate) enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Dang, T.T., Chen, X. and Facchini, P.J. Acetylation serves as a protective group in noscapine biosynthesis in opium poppy. Nat. Chem. Biol. 11 (2015) 104–106. [DOI] [PMID: 25485687] |
| 2. |
Li, Y. and Smolke, C.D. Engineering biosynthesis of the anticancer alkaloid noscapine in yeast. Nat. Commun. 7:12137 (2016). [DOI] [PMID: 27378283] |
| 3. |
Li, Y., Li, S., Thodey, K., Trenchard, I., Cravens, A. and Smolke, C.D. Complete biosynthesis of noscapine and halogenated alkaloids in yeast. Proc. Natl. Acad. Sci. USA 115 (2018) E3922–E3931. [DOI] [PMID: 29610307] |
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| [EC 1.14.14.167 created 2018] |
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