The Enzyme Database

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EC 1.14.14.183     
Accepted name: taxoid 2α-hydroxylase
Reaction: (1) taxusin + [reduced NADPH—hemoprotein reductase] + O2 = 2α-hydroxytaxusin + [oxidized NADPH—hemoprotein reductase] + H2O
(2) 7β-hydroxytaxusin + [reduced NADPH—hemoprotein reductase] + O2 = 2α,7β-dihydroxytaxusin + [oxidized NADPH—hemoprotein reductase] + H2O
Glossary: taxusin = taxa-4(20),11-diene-5α,9α,10β,13α-tetrayl tetraacetate
Systematic name: taxusin, [reduced NADPH—hemoprotein reductase]:oxygen 2-oxidoreductase
Comments: A cytochrome P-450 (heme-thiolate) protein from the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Chau, M., Jennewein, S., Walker, K. and Croteau, R. Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7β-hydroxylase. Chem. Biol. 11 (2004) 663–672. [DOI] [PMID: 15157877]
2.  Chau, M. and Croteau, R. Molecular cloning and characterization of a cytochrome P450 taxoid 2α-hydroxylase involved in taxol biosynthesis. Arch. Biochem. Biophys. 427 (2004) 48–57. [DOI] [PMID: 15178487]
[EC 1.14.14.183 created 2022]
 
 


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