The Enzyme Database

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Accepted name: taxane 9α-hydroxylase
Reaction: 5,20-epoxytax-11-en-4α-ol + [reduced NADPH—hemoprotein reductase] + O2 = 5,20-epoxytax-11-ene-4α,9α-diol + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s): taxoid 9α hydroxylase; CYP725A22; T9αOH
Systematic name: 5,20-epoxytax-11-en-4α-ol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (9α-hydroxylating)
Comments: The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Zhang, Y., Wiese, L., Fang, H., Alseekh, S., Perez de Souza, L., Scossa, F., Molloy, J., Christmann, M. and Fernie, A.R. Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis. Mol. Plant 16 (2023) 1951–1961. [DOI] [PMID: 37897038]
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