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Your query returned 1 entry. 
Printable version
| EC | 1.14.14.24 | ||||||||
| Accepted name: | vitamin D 25-hydroxylase | ||||||||
| Reaction: | calciol + O2 + [reduced NADPH—hemoprotein reductase] = calcidiol + [oxidized NADPH—hemoprotein reductase] + H2O | ||||||||
| For diagram of calciferol biosynthesis, click here | |||||||||
| Glossary: | calciol = cholecalciferol = vitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3-ol calcidiol = 25-hydroxyvitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol |
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| Other name(s): | vitamin D2 25-hydroxylase; vitamin D3 25-hydroxylase; CYP2R1 | ||||||||
| Systematic name: | calciol,NADPH—hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating) | ||||||||
| Comments: | A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase. | ||||||||
| Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB | ||||||||
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