ExplorEnz: EC 1.14.14.31

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1.14.14.31

Accepted name:

ipsdienol synthase

Reaction:

myrcene + [reduced NADPH—hemoprotein reductase] + O₂ = (R)-ipsdienol + [oxidized NADPH—hemoprotein reductase] + H₂O

For diagram of acyclic monoterpenoid biosynthesis, click here

Glossary:

myrcene = 7-methyl-3-methyleneocta-1,6-diene
ipsdienol = 2-methyl-6-methyleneocta-2,7-dien-4-ol

Other name(s):

myrcene hydroxylase; CYP9T2; CYP9T3

Systematic name:

myrcene,NADPH—hemoprotein reductase:O₂ oxidoreductase (hydroxylating)

Comments:

A cytochrome P-450 heme-thiolate protein. Involved in the insect aggregation pheromone production. Isolated from the pine engraver beetle, Ips pini. A small amount of (S)-ipsdienol is also formed. In vitro it also hydroxylated (+)- and (–)-α-pinene, 3-carene, and (+)-limonene, but not α-phellandrene, (–)-β-pinene, γ-terpinene, or terpinolene.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Sandstrom, P., Welch, W.H., Blomquist, G.J. and Tittiger, C. Functional expression of a bark beetle cytochrome P450 that hydroxylates myrcene to ipsdienol. Insect Biochem. Mol. Biol. 36 (2006) 835–845. [DOI] [PMID: 17046597]
2.	Song, M., Kim, A.C., Gorzalski, A.J., MacLean, M., Young, S., Ginzel, M.D., Blomquist, G.J. and Tittiger, C. Functional characterization of myrcene hydroxylases from two geographically distinct Ips pini populations. Insect Biochem. Mol. Biol. 43 (2013) 336–343. [DOI] [PMID: 23376633]

[EC 1.14.14.31 created 2015 as EC 1.14.13.207, transferred 2016 to EC 1.14.14.31]