ExplorEnz: EC 1.14.14.65

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1.14.14.65

Accepted name:

sugiol synthase

Reaction:

ferruginol + 2 [reduced NADPH—hemoprotein reductase] + 2 O₂ = sugiol + 2 [oxidized NADPH—hemoprotein reductase] + 3 H₂O

For diagram of carnosic acid, salviol and suginol diterpenoids biosynthesis, click here

Glossary:

ferruginol = abieta-8,11,13-trien-12-ol
sugiol = 12-hydroxyabieta-8,11,13-trien-7-one

Other name(s):

CYP76AH3

Systematic name:

ferruginol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (sugiol-forming)

Comments:

A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11-hydroxysugiol. It also oxidizes at C-12 of ferruginol (EC 1.14.14.60 ferruginol monooxygenase).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Guo, J., Ma, X., Cai, Y., Ma, Y., Zhan, Z., Zhou, Y.J., Liu, W., Guan, M., Yang, J., Cui, G., Kang, L., Yang, L., Shen, Y., Tang, J., Lin, H., Ma, X., Jin, B., Liu, Z., Peters, R.J., Zhao, Z.K. and Huang, L. Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones. New Phytol. 210 (2016) 525–534. [DOI] [PMID: 26682704]

[EC 1.14.14.65 created 2018]