ExplorEnz: EC 1.14.14.67

Your query returned 1 entry. Printable version

1.14.14.67

Accepted name:

11-hydroxysugiol 20-monooxygenase

Reaction:

11-hydroxysugiol + [reduced NADPH—hemoprotein reductase] + O₂ = 11,20-dihydroxysugiol + [oxidized NADPH—hemoprotein reductase] + H₂O

For diagram of carnosic acid, salviol and suginol diterpenoids biosynthesis, click here

Glossary:

ferruginol = abieta-8,11,13-trien-12-ol
sugiol = 12-hydroxyabieta-8,11,13-trien-7-one

Other name(s):

CYP76AK1

Systematic name:

11-hydroxysugiol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (11,20-dihydroxysugiol-forming)

Comments:

A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11,20-dihydroxyferruginol.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Guo, J., Ma, X., Cai, Y., Ma, Y., Zhan, Z., Zhou, Y.J., Liu, W., Guan, M., Yang, J., Cui, G., Kang, L., Yang, L., Shen, Y., Tang, J., Lin, H., Ma, X., Jin, B., Liu, Z., Peters, R.J., Zhao, Z.K. and Huang, L. Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones. New Phytol. 210 (2016) 525–534. [DOI] [PMID: 26682704]

[EC 1.14.14.67 created 2018]