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Your query returned 1 entry. Printable version
EC | 1.14.14.73 | ||||||||||
Accepted name: | albendazole monooxygenase (sulfoxide-forming) | ||||||||||
Reaction: | (1) albendazole + [reduced NADPH—hemoprotein reductase] + O2 = albendazole S-oxide + [oxidized NADPH—hemoprotein reductase] + H2O (2) fenbendazole + [reduced NADPH—hemoprotein reductase] + O2 = fenbendazole S-oxide + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of albendazole metabolism, click here | |||||||||||
Glossary: | albendazole = methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate fenbendazole = methyl [5-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbamate |
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Other name(s): | albendazole sulfoxidase (ambiguous); albendazole hydroxylase (ambiguous); CYP3A4 (gene name); CYP2J2 (gene name); CYP1A2 (gene name) | ||||||||||
Systematic name: | albendazole,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (sulfoxide-forming) | ||||||||||
Comments: | This is one of the activities carried out by some microsomal cytochrome P-450 monooxygenases. A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32, albendazole monooxygenase (flavin-containing)), but it is estimated that cytochrome P-450s are responsible for 70% of the activity. | ||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9059-22-7 | ||||||||||
References: |
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