The Enzyme Database

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Accepted name: isoflavone 2′-hydroxylase
Reaction: an isoflavone + [reduced NADPH—hemoprotein reductase] + O2 = a 2′-hydroxyisoflavone + [oxidized NADPH—hemoprotein reductase] + H2O
For diagram of the biosynthesis of formononetin and derivatives, click here
Other name(s): isoflavone 2′-monooxygenase; CYP81E1; CYP Ge-3
Systematic name: isoflavone,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2′-hydroxylating)
Comments: A cytochrome P-450 (heme-thiolate) protein. Acts on daidzein, formononetin and genistein. EC, 4′-methoxyisoflavone 2′-hydroxylase, has the same reaction but is more specific as it requires a 4′-methoxyisoflavone.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 110183-49-8
1.  Akashi, T., Aoki, T. and Ayabe, S.-I. CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2′-hydroxylase. Biochem. Biophys. Res. Commun. 251 (1998) 67–70. [DOI] [PMID: 9790908]
[EC created 2005 as EC, transferred 2018 to EC]

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