The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: protopine 6-monooxygenase
Reaction: protopine + [reduced NADPH—hemoprotein reductase] + O2 = 6-hydroxyprotopine + [oxidized NADPH—hemoprotein reductase] + H2O
For diagram of stylopine biosynthesis, click here
Other name(s): protopine 6-hydroxylase; CYP82N2 (gene name)
Systematic name: protopine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)
Comments: A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 128561-60-4
1.  Tanahashi, T. and Zenk, M.H. Elicitor induction and characterization of microsomal protopine-6-hydroxylase, the central enzyme in benzophenanthridine alkaloid biosynthesis. Phytochemistry 29 (1990) 1113–1122.
2.  Takemura, T., Ikezawa, N., Iwasa, K. and Sato, F. Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells. Phytochemistry 91 (2013) 100–108. [PMID: 22421633]
[EC created 1999 as EC, transferred 2018 to EC]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald